Questions about the loco-regional, deep hyperthermia procedure and the Celsius TCS modality.
What types of hyperthermia are there?
First of all, it is useful to make the distinction between active and passive hyperthermia. The aim of active hyperthermia, which is also called fever therapy, is to increase the body temperature using bacterial toxins or by influencing the cytokines.
However, today the term “hyperthermia” is usually used in the sense of passive hyperthermia whereby the heat is introduced or induced externally. Differences here include:
a. Whole-body hyperthermia
To treat tumours/metastases that have spread to multiple organs or systemic tumour illnesses
b. Surface hyperthermia
To treat skin tumours and metastases (suitable for treatment using Celsius TCS)
c. Loco-regional deep hyperthermia
To treat solid tumours in organs such as the liver, lungs, brain, pelvic area and the like (suitable for treatment using Celsius TCS)
d. Perfusion hyperthermia
For hyperthermal perfusion of metastasised hollow organs or spaces
e. Interstitial thermotherapy
Special targeted method
For which types of tumour can Celsius TCS be used?
The loco-regional deep hyperthermia method is a suitable treatment for solid tumours such as:
• Anal cancer
• Bronchial cancer
• CUP syndrome
• Cancer of the small intestine
• Ewing’s sarcoma
• Gall bladder and bile duct cancer
• Urinary tract cancer
• Testicular cancer
• Colon cancer
• Head and neck cancer
• Endometrial cancer
• Liver cancer
• Stomach cancer
• Breast cancer
• Malign melanoma
• Nasopharynx cancer
• Renal cell cancer
• Renal pelvic cancer
• Esophageal cancer
• Ovarian cancer
• Pancreatic cancer
• Prostate cancer
• Rectal cancer
• Thyroid cancer
• Vaginal cancer
• Vulvar cancer
• Soft tissue cancer
• Cervical cancer
What are the contraindications of loco-regional deep hyperthermia?
Cardiac pacemakers and other pacemaker electrodes are contraindicated as it is not possible to guarantee that the electronics of the pacemaker will not be destroyed, causing malfunctions. Furthermore, implants in the target area are problematic, as is the treatment of bone marrow transplant patients.
Is treatment with Celsius TCS painful and what are the side effects?
In contrast to surgery, chemotherapy and radiation therapy, hyperthermia has almost no side effects. On the contrary: patients often report feeling the positive, calming benefits of the heat. They regularly report a “calming” sensation and reduced stress.
Some tiredness can occur after treatment. In rare cases, the increased death of malignant cells can result in slight fever spikes. In general, however, this is considered to be a positive physical sign.
Patients with a disrupted perception of temperature (for example following a stroke) must be observed constantly during treatment. The hyperthermia area must be monitored continuously throughout the procedure (i.e. to avoid sweat accumulation; sweat can heat up excessively and result in blisters on the skin). Otherwise, every patient is given a push-button that can be used at any time to interrupt the treatment if he/she feels an uncomfortable heat sensation.
Why is loco-regional deep hyperthermia suitable as a complementary method to radiation therapy?
Different mechanisms are responsible for the supra-additive effect of hyperthermia when used in conjunction with radiotherapy. The additive, complementary effect of hyperthermia is due to the higher heat sensitivity of cells in the S phase, which are relatively radio-resistant. Hyperthermia can also cause increased blood flow and thus increased tissue oxygenation, which results in increased radio-sensitivity. Therefore, it is best to perform hyperthermia before or during radiotherapy; alternatively, hyperthermia can also be administered immediately after radiation.
Hyperthermia increases cytotoxic radiation effects, particularly by interfering with the cellular repair system as a result of the denaturing of the DNA. In vivo studies have shown that hyperthermia can boost the effect of radiotherapy by a factor of 1.2 to 5. Hyperthermia is probably the most potent radio-sensitising method currently known.
Loco-regional hyperthermia as a complementary treatment to radiotherapy
The primary mechanism of radiotherapy is the generation of free oxygen radicals by ionising radiation, which in turn attack the DNA of tumour cells. Cells low in oxygen are three times more resistant to gamma radiation than normal cells. This is where hyperthermia can be a complementary treatment. Due to the heating of the tissue, blood flow increases, resulting in higher oxygen enrichment in the affected tissue. Another important effect is the inhibition of the cancer cells’ own DNA repair mechanisms because the heat releases heat-shock proteins. Thus, hyperthermia is probably the most effective support to radiotherapy available today.
Why is loco-regional deep hyperthermia suitable as a complementary treatment to chemotherapy?
Hyperthermia is normally administered in parallel with chemotherapy. Hyperthermia generally enhances the effects of chemotherapy on the tumour. The most important reason for this is that capillary vessels in the tumour tissue generally have no muscle layer (steel phenomenon) and thus are not able to expand when overheated, unlike the microvessels in adjacent healthy tissue.
Since under normal temperature conditions during chemotherapy a higher blood flow occurs in the tumour tissue first, the cytostatic drugs in the tumour tissue diffuse more strongly. With the subsequent targeted hyperthermia of the tumour region and the adjacent healthy tissue, the blood flow ratio changes such that the drugs in the tumour tissue cannot be flushed out as easily, and at the same time blood perfusion in the surrounding healthy tissue is now higher and thus the cytostatic drugs can be evacuated more easily.
Furthermore, the permeability of the capillary vessels in the tumour is increased by the insufficient (lack of) wall build-up under the influence of heat, thus accelerating the absorption of cytostatic drugs by the cancer cells.
Thus, in some cases, previously ineffective chemotherapy can become an effective treatment thanks to hyperthermia.
Loco-regional hyperthermia as a complementary treatment to chemotherapy
Confirmed by the results of a new study, it has been shown that hyperthermia has a significantly stronger impact compared to pure chemotherapy (e.g. Issels 2007 for sarcomas; Jones 2007 for breast cancer, among others).
The technique of loco-regional deep hyperthermia heats up the tumour cells using high-frequency waves and affects the metabolism of the cells and the extracellular environment.
This causes the cellular metabolism of the cancer cells to change locally to such an extent that programmed destruction can be induced (apoptosis).
Meanwhile, it has been proven repeatedly that heating a tumour can inhibit the growth of tumour cells, shrink tumours and even result in complete healing.
Does statutory insurance pay for Celsius TCS treatment?
Since loco-regional electro deep hyperthermia is an innovative and new form of therapy, in accordance with §12 of the German SGBV, health insurance companies are not obligated to pay for it. However, an application for reimbursement can be lodged. Following a decision by the German Federal Court of Justice (BGH) in August 2006, an insurance agency was ordered to cover the treatment costs in an individual case. This decision can be downloaded from the customer area. Otherwise, the costs for loco-regional deep hyperthermia are normally billed at the simple rate of the German scale of charges for doctors (GOÄ) (according to GOÄ Section 5854 (145.14 Euro) per treatment session).
What is the essential advantage of Celsius TCS systems compared with competitors' methods?
Celsius TCS does not operate on a microwave basis, but uses a carrier frequency of 13.5MHz. With this frequency, heat can reach even deeper layers of body tissue without having to use expensive antenna arrays. By using two active electrodes that can be tailored to the individual target area in terms of size, output and cooling, it is possible to effectively reach deeper regions as well.
Do you have any references?
We would be happy to arrange a reference visit to one of our customers on request. Just give us a call. You can find a selection of our clients under the keyword “References”.
To what extent can Celsius TCS be incorporated into an organisational structure?
Celsius TCS was developed from a profound knowledge of requirements from the procedural point of view of an organisation. There is a workflow overview that can be called up rapidly to provide a clear overview of all patients undergoing active treatment. Furthermore, a medical documentation feature, which collects and stores all relevant parameters, is included. Wherever possible, data is collected by the Celsius TCS modality in order to reduce user input to a minimum and to store all relevant treatment parameters.
Does the Celsius TCS have a valid CE Certification according to the Medical Products Law?
Yes, Celsius TCS is certified in the more stringent MPG Class IIb and has corresponding CE certification. This CE certification can be viewed on this website.